Nonprofit grants in South Carolina

Two kinds of funding are open to South Carolina nonprofits right now: 3 federal opportunities that specifically mention South Carolina (state-targeted programs, regional set-asides, or South Carolina-based eligibility), and the nationwide pool (639 nonprofit-eligible grants in total) that any U.S. 501(c)(3) can pursue. Both lists below are live — refreshed every morning from grants.gov and sorted by what closes next.

South Carolina-specific opportunities

Opportunity	Agency	Deadline	Award ceiling	Eligible
NRCS' Feral Swine Eradication and Control Pilot Program Fiscal Year (FY) 2026 Agriculture Environment Natural Resources	Natural Resources Conservation Service	September 21, 2026 12d left	$3M	Nonprofits
Limited Competition: Centers of Biomedical Research Excellence: Expansion/Sustainability Phases (COBRE-E/S) (P30 - Clinical Trial Not Allowed) Health	National Institutes of Health	May 25, 2029	—	Nonprofits
Limited Competition: Centers of Biomedical Research Excellence: Development Phase (COBRE-D) (P30 - Clinical Trial Not Allowed) Health	National Institutes of Health	May 26, 2029	—	Nonprofits

Nationwide grants any South Carolina nonprofit can apply for (closing soonest)

Opportunity	Agency	Deadline	Award ceiling	Eligible
A Science of Science Approach to Analyzing and Innovating the Biomedical Research Enterprise Science and Technology	U.S. National Science Foundation	September 9, 2026 0d left	$250k	Nonprofits
NIH Director’s Pioneer Award (DP1 Clinical Trial Optional) Health	National Institutes of Health	September 9, 2026 0d left	$700k	Nonprofits
FY 2026 Notice of Funding Opportunity: Innovative Coordinated Access and Mobility Pilot Program Transportation	DOT - Federal Transit Administration	September 9, 2026 0d left	—	Nonprofits
OVW Fiscal Year 2026 STCJ Technical Assistance - Request for Required Documents Law, Justice and Legal Services	Office on Violence Against Women	September 9, 2026 0d left	$900k	Nonprofits
NIH Director’s Early Independence Award (DP5 Clinical Trial Optional) Health	National Institutes of Health	September 10, 2026 1d left	$350k	Nonprofits
DoW Vision, Mentored Clinical Research Award Science and Technology	Defense Health Agency Contracting Activity - DHACA	September 10, 2026 1d left	—	Nonprofits
DoW Hearing Restoration Focused Research Award Science and Technology	Defense Health Agency Contracting Activity - DHACA	September 10, 2026 1d left	—	Nonprofits
Enhancing and Supporting the Network of American Spaces in Armenia Other	U.S. Mission to Armenia	September 10, 2026 1d left	$111k	Nonprofits
FY26 Bureau of Land Management Threatened and Endangered Species - Bureau wide Natural Resources	Bureau of Land Management	September 11, 2026 2d left	$1M	Nonprofits
FY26 Bureau of Land Management Wildlife Resource Management Program - Bureau wide Natural Resources	Bureau of Land Management	September 11, 2026 2d left	$2M	Nonprofits
Countering CCP Influence in Panama's Unviersities Regional Development	U.S. Mission to Panama	September 13, 2026 4d left	$150k	Nonprofits Individuals
Equipping Journalists to Counter Anti-American Propaganda Regional Development	U.S. Mission to Panama	September 13, 2026 4d left	$120k	Nonprofits Individuals
Improving the Capacity of Tribal Communities to Identify Emerging Drug Threats Health	Office of National Drug Control Policy	September 13, 2026 4d left	$300k	Nonprofits
Lead-Safe and Healthy Homes Financing Demonstration Housing	Department of Housing and Urban Development	September 14, 2026 5d left	$10M	Nonprofits
DoW Neurofibromatosis Research Academy – Leadership Award Science and Technology	Defense Health Agency Contracting Activity - DHACA	September 14, 2026 5d left	—	Nonprofits

Browse all 639 nonprofit-eligible grants →

South Carolina grants by category

Nonprofit grants in South Carolina

South Carolina-specific opportunities

Nationwide grants any South Carolina nonprofit can apply for (closing soonest)

South Carolina grants by category

Deadline alerts for South Carolina nonprofits