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Seed Instrumentation Support (SIS) Program (S10 Clinical Trial Not Allowed)

National Institutes of Health · Opportunity PAR-27-021

Deadline July 1, 2028 661 days left
Award range $50k – $400k
Total program funding
PostedJune 25, 2026

Who can apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

About this opportunity

This Notice of Funding Opportunity (NOFO) aims to build new research capacity and develop a sustainable research program by supporting the purchase of a single commercially available biomedical research instrument currently unavailable in the institution. Instruments funded through this program must be shared among the users to create new research opportunities, enable reproducible data generation, encourage collaborative research and training, and strengthen long-term research capabilities. The minimum award is $50,000. While there is no limit on the total cost of the instrument, the maximum award is $400,000.

Portfolio context — this listing covers more than this opportunity

This opportunity is funded under Assistance Listing 93.310 (“Trans-NIH Research Support”), a broad federal program that made about 574 new awards per year over the last five fiscal years (median award $981k). Those figures describe that whole portfolio — not this specific solicitation, so we don't show them as if they were this opportunity's track record.

Applicant counts per solicitation are not published by any federal agency — no one can honestly sell you that number. NIH publishes success rates by institute and activity code — source.

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