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Limited Competition: Small Grant Program for NIDDK K01/K08/K23/K25 Recipients (R03 Clinical Trial Optional)

National Institutes of Health · Opportunity PAR-25-091

Deadline January 7, 2028 485 days left
Award range Up to $75k
Total program funding
PostedJanuary 10, 2025

Who can apply

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

About this opportunity

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) announces a program that provides NIDDK-supported K01, K08, K23, and K25 recipients the opportunity to apply for Small Grant (R03) support at some point during the latter years of their award period of their K award. Through the use of this mechanism, the NIDDK is seeking to enhance the capability of its K01, K08, K23, and K25 award recipients to conduct research as they complete their transition to fully independent investigator status. The R03 grant mechanism supports different types of projects, including pilot and feasibility studies; secondary analysis of existing data; small, self-contained research projects; development of research methodology; and development of new research technology. The R03 is, therefore, intended to support research projects that can be carried out in a short period of time with limited resources and that may provide preliminary data to support a subsequent R01, or equivalent, application.

Award history — this exact opportunity

NIH RePORTER lists 31 funded awards under PAR-25-091 across 26 organizations.

Awards by fiscal year 2026: 31
Award size (min / median / max) $96k / $123k / $158k

Total award obligations, not per-year amounts.

Recent awardees include: COLUMBIA UNIVERSITY HEALTH SCIENCES, BOSTON CHILDREN'S HOSPITAL, CHILDREN'S HOSP OF PHILADELPHIA, MASSACHUSETTS GENERAL HOSPITAL, BAYLOR COLLEGE OF MEDICINE, UNIVERSITY OF MICHIGAN AT ANN ARBOR, UNIVERSITY OF WASHINGTON, CEDARS-SINAI MEDICAL CENTER.

Source: NIH RePORTER, matched on the exact opportunity number. NIH publishes success rates by institute and activity code — source.

Portfolio context — this listing covers more than this opportunity

This opportunity is funded under Assistance Listing 93.847 (“Diabetes, Digestive, and Kidney Diseases Extramural Research”), a broad federal program that made about 907 new awards per year over the last five fiscal years (median award $453k). Those figures describe that whole portfolio — not this specific solicitation, so we don't show them as if they were this opportunity's track record.

Applicant counts per solicitation are not published by any federal agency — no one can honestly sell you that number. NIH publishes success rates by institute and activity code — source.

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