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NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed)

National Institutes of Health · Opportunity PA-25-304

Deadline January 7, 2028 485 days left
Award range Not stated
Total program funding
PostedDecember 18, 2024

Who can apply

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

About this opportunity

The NIH Exploratory/Developmental Grant supports exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research.

Award history — this exact opportunity

NIH RePORTER lists 918 funded awards under PA-25-304 across 175 organizations.

Awards by fiscal year 2025: 5 · 2026: 495
Award size (min / median / max) $16k / $421k / $534k

Total award obligations, not per-year amounts.

Recent awardees include: UNIV OF NORTH CAROLINA CHAPEL HILL, WASHINGTON UNIVERSITY, UNIVERSITY OF PITTSBURGH AT PITTSBURGH, UNIVERSITY OF MINNESOTA, EMORY UNIVERSITY, UNIVERSITY OF FLORIDA, DUKE UNIVERSITY, JOHNS HOPKINS UNIVERSITY.

Source: NIH RePORTER, matched on the exact opportunity number. NIH publishes success rates by institute and activity code — source.

Portfolio context — this listing covers more than this opportunity

This opportunity is funded under Assistance Listing 93.113 (“Environmental Health”), a broad federal program that made about 246 new awards per year over the last five fiscal years (median award $468k). Those figures describe that whole portfolio — not this specific solicitation, so we don't show them as if they were this opportunity's track record.

Applicant counts per solicitation are not published by any federal agency — no one can honestly sell you that number. NIH publishes success rates by institute and activity code — source.

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