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NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Required)

National Institutes of Health · PA-25-306 · Deadline: January 7, 2028

Opportunity-exact history — these numbers describe this specific funding opportunity (PA-25-306), from NIH RePORTER.

Awards under this opportunity 31

to 29 distinct organizations. By FY: 2026: 31

Actual award size $410k median

range $195k – $477k

Listing summary

The NIH Exploratory/Developmental Grant supports exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research. This Parent Notice of Funding Opportunity requires that at least 1 clinical trial be proposed. The proposed project must be related to the programmat…

Eligibility: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities, Native American tribal organizations (other), Nonprofits with 501(c)(3), other than higher education, Nonprofits without 501(c)(3), Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others · Categories: Education, Environment, Health, Income Security and Social Services · official listing ↗

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Sources: NIH RePORTER (opportunity-exact) and USAspending (program-level), labeled per section. GrantsDue computes summaries only; verify anything critical against the originals. Methodology.